Secreted.

Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.

Belongs to the IL-2 family.

Entrez Gene: 3558 Human

Entrez Gene: 16183 Mouse

Entrez Gene: 116562 Rat

Omim: 147680 Human

SwissProt: P60568 Human

SwissProt: P04351 Mouse

SwissProt: P17108 Rat

Unigene: 89679 Human

Unigene: 14190 Mouse

Unigene: 9871 Rat

The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]